Afectación del apéndice cecal y simulación de una apendicitis aguda en un cuadro intestinal por Campylobacter jejuni / Cecal appendix involvement and simulation of an acute appendicitis in a patient with bowel disease produced by Campylobacter jejuni

Campylobacter jejuni es una de las causas de diarrea aguda por infección entérica más frecuente en el niño. Se encuentra ampliamente distribuido en nuestro medio, y las aves de consumo y sus subproductos son los principales reservorios y fuente de infección humana. Pese a que la clínica más frecuente es de diarrea acuosa con fiebre, esta puede simular otros cuadros abdominales más graves, como puede ser una apendicitis aguda, con dolor abdominal y signos de irritación peritoneal en la fosa ilíaca derecha, lo que puede conducir a una intervención quirúrgica si no se realiza un correcto diagnóstico diferencial. Se presenta un caso tratado en nuestro hospital, del que se discuten los mecanismos etiológicos, los aspectos clínicos y el manejo terapéutico óptimo (AU)

Campylobacter jejuni is one of the most frequent causes of acute diarrhea in children. This germ is found widely distributed in our environment. Poultry and their products are the main reservoir and source of infection in humans. Although the most common presentation is watery diarrhea with fever, it can mimic other more serious abdominal problems, such as acute appendicitis. It may present with abdominal pain and signs of peritoneal irritation at the right iliac fossa, leading to surgery if there is not a correct differential diagnosis. We report a case treated in our hospital, discussing etiological mechanisms, clinical aspects and optimal therapeutic management (AU)

Synthesis and anabolic/androgenic evaluation of novel 9alpha-fluorosteroids.

3Beta,11beta-dihydroxy-9alpha-fluor-5alpha-androstane-17-one (2), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane-17-one (3), 3beta-acetoxy-9alpha-fluor-11beta,17beta-dihydroxy-5alpha-androstane (4), 3beta,17beta-diacetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane (5), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-propionate (6), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-enanthate (7), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-isobutyrate (8) were synthesized in the present study. Compounds 2 and 8 exhibited higher anabolic activity than the rest of the synthesized compounds. The structure of all these newly synthesized compounds was confirmed by analytic spectral data (mass, (1)H NMR and (13)C NMR).